The R726 is a Regional Route in South Africa. Its north-western terminus is the R26 at Zastron, Free State. It heads south-east into the Eastern Cape to meet the R392 near Sterkspruit.
The R726's north-western terminus is a junction with R26 road just north of Zastron. It heads south-east for 45 kilometres to cross the Majaphuthi Bridge on the Orange River and reach its end at a junction with the R392 and R393 at the village of Masaleng, 6 kilometres north of Sterkspruit.