The R563 is a Regional Route in the Mogale City Local Municipality in Gauteng, South Africa. It connects Hekpoort with Krugersdorp.
Its north-western terminus is the R560 at Hekpoort. It runs south-east, past Sterkfontein caves, before crossing the N14 national route at a staggered junction and entering Krugersdorp to end at an intersection with the M36 metropolitan route (Commissioner Street).