The R561 is a Regional Route in Limpopo, South Africa that connects Marken with the Zanzibar border post with Botswana via Baltimore.
Its northern origin is the Zanzibar border post with Botswana on the Limpopo River. It heads south for 22 kilometres to cross the R572 at a staggered junction in the village of Maasstroom. It continues southwards for 66 kilometres to cross the N11 at a staggered junction in the village of Baltimore. It continues southwards for 37 kilometres to end at an intersection with the R518 in Marken.