The R559 is a Regional Route in Gauteng, South Africa that connects Protea Glen with Carletonville via Randfontein.
The R559 begins at a junction with the R558 road in Protea Glen, Soweto, just north of the R558's intersection with the N12. It goes north-west for 17 kilometres to reach a junction with the R28 road in the southern suburbs of Randfontein (just north of Mohlakeng).
From Randfontein, it turns to the south-west and goes for 22 kilometres, through Hillside, to reach a junction with Station Street. It becomes Station Street westwards and goes for 17 kilometres to enter the towns of Oberholzer and Carletonville. It reaches a junction with the R500 road and bypasses Carletonville Mall. From the R500 junction, it goes westwards for 18 kilometres, passing south of Khutsong, to reach its western terminus at a junction with the R501 road.