Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C<sub>4</sub>N<sub>2</sub> ring. Two isomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in medicinal chemistry.
Common routes to quinazolines involve condensation of amides to anilines with ortho nitrile, carboxylic acids and amides.
Quinazolinone drugs that function as hypnotic/sedatives, methaqualone (Quaalude) for example, usually contain a 4-quinazolinone core with a 2-substituted phenyl group at nitrogen atom 3.