Quezaltepeque () is a municipality, with a population of 28,075 (2018 census) and an area of 239 km<sup>2</sup>, in the Chiquimula department of Guatemala. The local economy is based on agriculture. Agricultural products include coffee, maize and beans. As of 1993, there was a working telegraph terminal there in the post office.
QuetzaltepÃÂc is Nahuatl for "At the quetzal-feather hill". The British spelled it Quesaltpeque, in the 19th century.
As of 1850, the municipality had an estimated population of 4,000.