Quettreville-sur-Sienne () is a commune in the Manche department in north-western France. On 1 January 2016, the former commune of Hyenville was merged into Quettreville-sur-Sienne. On 1 January 2019, the former communes of Contrières, Guéhébert, Hérenguerville and Trelly were merged into Quettreville-sur-Sienne. The river Sienne flows through the town.
Population data refer to the area corresponding with the commune as of January 2025.