Quebec Run is a long 3rd order tributary to Big Sandy Creek in Fayette County, Pennsylvania. This is the only stream of this name in the United States.
According to the Geographic Names Information System, it has also been known historically as:
Quebec Run rises about 2 miles northeast of Wymps Gap, Pennsylvania, and then flows east and southeast to join Big Sandy Creek about 4 miles southwest of Elliottsville.
Quebec Run drains of area, receives about 50.9 in/year of precipitation, has a wetness index of 320.85, and is about 94% forested.