Quamby Brook is a rural locality in the local government area of Meander Valley in the Launceston region of Tasmania. It is located about south-west of the town of Launceston. The 2016 census determined a population of 106 for the state suburb of Quamby Brook.
Quamby Brook was gazetted as a locality in 1968.
The watershed of the Cluan Tiers forms part of the north-eastern boundary.
The C502 route (Bogan Road) passes through from north to south. The C503 route (Quamby Brook Road) starts at an intersection with C502 and runs to the north-west corner, where it exits.