Pyridoxal 5â²-phosphate synthase (glutamine hydrolysing) (EC 4.3.3.6, PdxST) is an enzyme with systematic name <small>D</small>-ribose 5-phosphate,<small>D</small>-glyceraldehyde 3-phosphate pyridoxal 5â²-phosphate-lyase. This enzyme catalyses the following chemical reaction
<small>D</small>-ribose 5-phosphate + <small>D</small>-glyceraldehyde 3-phosphate + <small>L</small>-glutamine pyridoxal 5â²-phosphate + <small>L</small>-glutamate + 3 H<sub>2</sub>O + phosphate (overall reaction)
:(1a) <small>L</small>-glutamine + H<sub>2</sub>O <small>L</small>-glutamate + NH<sub>3</sub>
:(1b) <small>D</small>-ribose 5-phosphate + <small>D</small>-glyceraldehyde 3-phosphate + NH<sub>3</sub> pyridoxal 5â²-phosphate + 4 H<sub>2</sub>O + phosphate
The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate.
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