Puerto Rico Highway 64 (PR-64) is a short divided highway in Mayagüez, Puerto Rico which serves as an alternate route to Puerto Rico Highway 2, beginning at Puerto Rico Highway 102 toward barrio Sabanetas. It meets PR-2 again near Añasco. It is mostly divided. It is also a route to the Mayagüez Port, where a ferry can be taken to Santo Domingo, Dominican Republic.