Puerto Rico Highway 16 (PR-16) is an urban road in Santurce, Puerto Rico. With a length of about , this highway extends from an interchange with PR-1, PR-26 and Avenida Juan Ponce de León (PR-25) to PR-1 south.
This is a short road with two lanes per direction on most of its length and is parallel to PR-1 (Expreso Luis Muñoz Rivera), near to the western terminus of PR-26 (Expreso Román Baldorioty de Castro). This road intersects with PR-35 (Avenida Manuel Fernández Juncos) and provides access to Puerto Rico Convention Center and Fernando Luis Ribas Dominicci Airport. This road is called Boulevard Román Baldorioty de Castro.