Psilopeganum is a genus of flowering plants of the family Rutaceae.
It is a monotypic genus, with only a single species: Psilopeganum sinense (, not to be confused with Ephedra/ma huang).
It is native to the Three Gorges Reservoir area, in the Hubei province of central China, where it has become endangered. A specimen exists at the New York Botanical Garden.
Psilopeganum sinense is one of the 50 fundamental herbs used in traditional Chinese medicine.