Ψ-DOM

ψ-DOM, or psi-DOM, also known as 2,6-dimethoxy-4-methylamphetamine or as Z-7, is a psychedelic drug of the phenethylamine, amphetamine, and Ψ-PEA families related to DOM. It is a positional isomer of DOM in which the methoxy group at the 5 position has been relocated to the 6 position. The drug is taken orally.

Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists ψ-DOM's dose as 15 to 25mg orally and its duration as 6 to 8hours. The effects of ψ-DOM were reported to include feeling weird or strange, closed-eye imagery, some visuals, introspection, feeling stoned, spaciness, lightheadedness, muscle tremors, palpitations, and diarrhea. The visuals were said to have been less than expected based on the intensity of its effects. The drug is about one-third as potent as DOM.

Interactions

Pharmacology

Pharmacodynamics

ψ-DOM shows affinity for the serotonin 5-HT_2A and 5-HT_2C receptors (K_i = 49–351nM and 50nM, respectively). Its affinity for the serotonin 5-HT_2A receptor was about 2.6- to 3.5-fold lower than that of DOM. The drug acts as an agonist of the serotonin 5-HT_2A receptor similarly to DOM.

ψ-DOM has been found to substitute for LSD and 5-MeO-DMT in rodent drug discrimination tests. Conversely, it did not substitute for the serotonin 5-HT_1A receptor agonist LY-293284 in such tests.

Chemistry

Synthesis

The chemical synthesis of ψ-DOM has been described.

Analogues

Analogues of ψ-DOM include other ψ-PEA derivatives like TMA-6 (ψ-TMA-2), Ψ-2C-T-4, and Ψ-DODFMO, among others.

History

Ψ-DOM was first described in the literature by Alexander Shulgin in 1970. Subsequently, it was described in greater detail by Shulgin in his 1991 book PiHKAL (Phenethylamines I have Known and Loved).

Society and culture

Legal status

Canada

Ψ-DOM is a controlled substance in Canada under phenethylamine blanket-ban language.

United States

Ψ-DOM is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption. In addition, it may be considered scheduled as a positional isomer of DOM.

See also

• Ψ-PEA (psychedelics)

References

External links

• ψ-DOM - Isomer Design
• ψ-DOM - PiHKAL - Erowid
• ψ-DOM - PiHKAL - Isomer Design