Progress M-43 () was a Russian unmanned Progress cargo spacecraft, which was launched in October 2000 to resupply the Mir space station.
Progress M-43 launched on 16 October 2000 from the Baikonur Cosmodrome in Kazakhstan. It used a Soyuz-U rocket. The launch had been delayed from the previous day.
Progress M-43 docked with Mir on 20 October 2000 at 21:16:05 UTC.
It remained in orbit until 29 January 2001, when it was deorbited. The deorbit burn occurred at 02:12 UTC.