Profondeville (; ) is a municipality of Wallonia located in the province of Namur, Belgium.
On January 1, 2016, Profondeville had a total population of 12,117. The total area of the municipality is and the population density is 240.70 inhabitants per km<sup>2</sup>.
The original municipality of Profondeville was expanded, during the post-1974 fusion of the Belgian municipalities, with the addition of the ancienne communes of Arbre, Bois-de-Villers, Lesve, Lustin, Rivière and the Lakisse area from the southeast of the newly-adjoining municipality of Floreffe.