Pristimantis medemi is a species of frog in the family Strabomantidae. The species is endemic to Colombia.
The specific name, medemi, is in honor of Federico Medem, who was a Colombian herpetologist of Baltic German descent.
Pristimantis medemi is found in central Colombia, in the departments of Caquetá, Casanare, Cundinamarca, and Meta.
The natural habitats of Pristimantis medemi are tropical moist lowland forests, moist montane forests, rivers, plantations, rural gardens, and heavily degraded former forests, at elevations of .
Pristimantis medemi is threatened by habitat loss.