The Presbyterian Secondary School, Osu also known as Osu PRESEC is a public secondary school in Accra.
The school was established in 1956 in one of the Old Basel Missionary buildings at the foot of Kuku Hill of Osu. The school was established to offer presbyterian day secondary education to children in Osu whose parents could not afford the boarding fees at Presbyterian Boys Senior Secondary school and to have a secondary school at Osu, in compensation for lack of a boarding school. The church and some individual educators teamed up to establish the school, with Cleland Armah as the first Headmaster.
In 1963, the school was absorbed into the public system under a new headmaster, Mr. McCarthy. He renovated the Old Basel Mission building into a school building accommodating two streams of classrooms, a library, an administration office and science laboratories. The church offered the present site, known as the "New Site". At the moment, the school has a block with eighteen classrooms and a three storey science block accommodating the staff. Currently, the school has benefited from the GETFund and new classroom blocks are being put up to accommodate the students.
The Presbyterian High School-Osu won over Mfantsipim School to win the Sprite Ball Championship for the first time, after beating Mfantsipim 25-22.
Point guard Joel Kobayere was named the most valuable player of the tournament. Presec-Osu won the championship in their second appearance at the tournament.