Pregnanolone, also known as eltanolone, is an endogenous inhibitory neurosteroid which is produced in the body from progesterone. It is closely related to allopregnanolone, which has similar properties.
Pregnanolone is a positive allosteric modulator of the GABA<sub>A</sub> receptor, as well as a negative allosteric modulator of the glycine receptor.
Pregnanolone has sedative, anxiolytic, anesthetic, and anticonvulsant effects. During pregnancy, pregnanolone and allopregnanolone are involved in sedation and anesthesia of the fetus.
Pregnanolone is synthesized from progesterone via the enzymes 5ò-reductase and 3ñ-hydroxysteroid dehydrogenase, with 5ò-dihydroprogesterone occurring as a metabolic intermediate. The elimination half-life of pregnanolone is between 0.9 and 3.5 hours.
Pregnanolone, also known as 3ñ,5ò-tetrahydroprogesterone (3ñ,5ò-THP) or as 5ò-pregnan-3ñ-ol-20-one, is a naturally occurring pregnane steroid and a derivative of progesterone. Related compounds include allopregnanolone (3ñ,5ñ-THP; brexanolone), epipregnanolone (3ò,5ò-THP), hydroxydione, isopregnanolone (3ò,5ñ-THP), and renanolone.
Pregnanolone was first isolated from the urine of pregnant women in 1937. Its anesthetic properties were first demonstrated in animals in 1957.
Pregnanolone was investigated for clinical use as a general anesthetic under the name eltanolone (), but produced unwanted side effects such as convulsions on occasion, and for this reason, was never marketed.