Prairietown is an unincorporated community and census-designated place (CDP) in Madison County, Illinois, United States. As of the 2020 census, it had a population of 153. It is part of the Metro East region of Greater St. Louis. Current Mayor Michael Schaefer has served 5 consecutive terms.
Prairietown is in northern Madison County, southwest of Staunton, east-northeast of Alton, and northeast of St. Louis.
According to the U.S. Census Bureau, Prairietown has an area of , all land. It drains to the west toward Joulters Creek and to the east toward Sherry Creek, both south-flowing tributaries of Cahokia Creek, which runs southwest to the Mississippi River.
Prairietown first appeared as a census designated place in the 2020 U.S. census.
It is in the Edwardsville Community Unit School District 7.