Pozzolo Formigaro is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about southeast of Turin and about southeast of Alessandria. As of 1 January 2022, it had a population of 4,507 and an area of .
Pozzolo Formigaro borders the following municipalities: Bosco Marengo, Cassano Spinola, Novi Ligure, Tortona, and Villalvernia.