Portimine A is a cyclic imine natural product produced by the dinoflagellate microalgae Vulcanodinium rugosum. It is a drug lead due to its anti-cancer activity. It seemingly inhibits ribosomal translation activity through an interaction with NMD3, leading to activation of the inflammasome. It is suspected to be causal toxin behind an severe inflammatory skin disease in Senegalese fishermen in 2020 and 2021.