Poole is a census-designated place (CDP) in Buffalo County, Nebraska, United States. It is part of the Kearney, Nebraska Micropolitan Statistical Area. As of the 2020 census, Poole had a population of 22.
Poole was founded circa 1889. It was named for rancher W. W. Poole. A post office was established at Poole in 1906, and remained in operation until it was discontinued in 1982.
Poole is located in northern Buffalo County on the north side of the South Loup River. The nearest incorporated community is Ravenna, to the northeast.
According to the United States Census Bureau, the Poole CDP has a total area of , of which , or 1.80%, is water.