Pompilio is a surname. Notable people with the surname include:
- Afrânio PompÃÂlio Gastos do Amaral (1894âÂÂ1982), Brazilian herpetologist
- Arsénio PompÃÂlio Pompeu de Carpo (1792âÂÂ1869), Portuguese slave trader, freemason, poet and journalist
- Elvis Pompilio (born 1961), Belgian fashion designer
- Luca Pompilio (born 1992), Italian footballer
- Numa Pompilio Llona (1832âÂÂ1907), Ecuadorian poet, journalist, educator, diplomat, and philosopher
- Pedro Pompilio (1949âÂÂ2008), Argentine businessman and football chairman