Pompey Centre District No. 10 Schoolhouse is a historic one-room school building located at Pompey Center in Onondaga County, New York. It is a one-story frame building on a stone foundation, 24 feet wide and 32 feet deep. The roof features a small belfry. It was built in 1857 and ceased being used as a school in 1943.
It was listed on the National Register of Historic Places in 1998.
A related 1840 schoolhouse in Pompey was destroyed by fire in January 2010.