Polygonum rupestre <small>Kar. & Kir.</small> is a species of flowering plant in the family Polygonaceae, native to Kazakhstan, Kyrgyzstan, Tajikistan and Uzbekistan. It was first described by Grigorij Silych Karelin and Ivan Kirilov in 1841.
(Polygonum rupestre <small>(Wedd.) Kuntze</small> is a different species, and is a synonym of Muehlenbeckia volcanica.)