Point Isabel may refer to several places in the United States:
- Point Isabel (promontory), on the eastern shore of San Francisco Bay, California
- Point Isabel Regional Shoreline, a multi-use park in Richmond, California
- Point Isabel, Indiana, an unincorporated community
- Point Isabel, Kentucky, now Burnside
- Point Isabel, Ohio, an unincorporated community
- Port Isabel, Texas, a city
- Point Isabel Light, a lighthouse
- Point Isabel Independent School District
- Point Isabel, Virginia, or Robley, an unincorporated community
See also