Pleasant Hill is a census-designated place and unincorporated community located in DeSoto County, Mississippi, United States, located approximately southwest of Hernando and southeast of Eudora, just east of Arkabutla Lake.
Pleasant Hill was formerly incorporated, and was home to several stores, two churches, and a Masonic lodge.
A post office operated under the name Pleasant Hill from 1848 to 1917.
It was first named as a CDP in the 2020 Census which listed a population of 1,863.