Piolenc (; ) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.
Piolenc is located north of Orange, and about north of Avignon.
Piolenc was the site of a Cluniac priory.
Wine is the main activity of this city, but the dominant besides of the agricultural production is the "French Provence garlic", as such the "garlic cultural festival" takes place every summer in August, during the last week-end.
Piolenc was the birthplace :
Piolenc is twinned with: