Pinkerton Run is a long 1st order tributary to Sewickley Creek in Westmoreland County, Pennsylvania.
Pinkerton Run rises about 0.5 miles west of Madison, Pennsylvania, and then flows south to join Sewickley Creek about 0.5 miles west of Yukon, Pennsylvania.
Pinkerton Run drains of area, receives about 40.2 in/year of precipitation, has a wetness index of 342.05, and is about 34% forested.