Pine Creek is a tributary of Mill Creek, which, in turn, is a tributary of the Neshaminy Creek, part of the Delaware River watershed.
Rising in Northampton Township, Pine Run flows in a southerly direction for about one-third its length before turning easterly, the finally southerly again to its confluence with Mill Creek at its 0.15 river mile. The watershed is about .
Pennsylvania Department of Environmental Protection designation is 02520.<br /> US Geological Survey designation is 1183875.
Pine Run lies within the Stockton Formation, a sedimentary layer of rock laid down during the Triassic. Mineralogy includes sandstone, arkosic sandstone, shale, siltstone, and mudstone.
Pine Run lies completely within Northampton Township.