Pierson Creek or Pearson Creek is a stream in southeastern Greene County in the Ozarks of southwest Missouri. The stream is a tributary of the James River.
The source area for the stream is about two miles west of Strafford and the stream flows south passing under I-44 then turns to the southwest. The stream enters the eastern portion of Springfield and turns south again as it crosses under Cherry Street. It flows under Missouri Route D and joins the James River about three miles northeast of the U.S. Route 60/U.S. Route 65 interchange of south Springfield.
The stream headwaters are at and the confluence with the James River is at . The confluence is at an elevation of and the elevation of the source is approximately .
The stream is the location of the type section for the Pierson Limestone as exposed near the Route D crossing.
The stream was named for a mill on the stream which was built by Jerry Pearson in 1828âÂÂ31. Pearson had acquired rights to the property from the Delaware Indians.