On 11 May 1987, Douglas C-47B C-FADD of Air Manitoba crashed near Pickle Lake after a structural failure of the port wing. The aircraft was on a domestic cargo flight from Big Trout Lake Airport to Pickle Lake Airport. Both crew were killed.
On 17 March 2017, Basler BT-67 C-FKGL of Private Air crashed on take-off for Big Trout Airport, Ontario. All three crew survived.