Phescaline (PH), also known as 4-phenoxy-3,5-dimethoxyphenethylamine, is a chemical compound of the phenethylamine and scaline families related to the psychedelic drug mescaline. It is the derivative of mescaline in which the methoxy group at the 4 position has been replaced with a phenoxy group.
According to Daniel Trachsel and colleagues in their book ', phescaline is not known to have been synthesized, studied, or tested in humans. However, analogues of phescaline like benzscaline (BZ) and 3C-BZ are known to be potent serotonin 5-HT<sub>2A</sub> receptor agonists and/or psychedelics, and phescaline may be active as a psychedelic similarly. On the other hand, the longer-chain analogue phenescaline was found to have little activity in humans at tested doses.
Phescaline was first described in the literature by Trachsel and colleagues in Phenethylamine: von der Struktur zur Funktion in 2013.