Petrella Tifernina is a comune (municipality) in the Province of Campobasso in the Italian region Molise, located about north of Campobasso. As of 31 December 2004, it had a population of 1,280 and an area of .
Petrella Tifernina borders the following municipalities: Castellino del Biferno, Limosano, Lucito, Matrice, Montagano.
The "Campo Sportivo" is located at the base of this village. It has a parking lot, a bar/convenience store, as well as a sports complex. It has generally replaced the village's piazza as the main gathering place for its residents.
Since the end of World War II until the 1970s, the town's population declined considerable due to emigration. The places of choice for these emigrants were the Canadian cities of Montreal and Toronto.