Peter and Karen McComb House is a historic home located in Poughkeepsie, Dutchess County, New York. It was designed by architect Marcel Breuer and constructed between 1950 and 1951. The original section is a small, one- to two-story, T-shaped frame dwelling built in the International style, featuring a concrete foundation. Three additions were constructed in 1962, 1988, and 1994. The house is built into its site atop a steep rock ridge and features large-scale rectangular window panels.
It was added to the National Register of Historic Places in 2009.