Perrysburg High School is a public high school in Perrysburg, Ohio, United States.
It is the only high school in Perrysburg Exempted Village School District (Perrysburg Schools).
Perrysburg High School was established in 1849. The school had its first graduating class in 1866. It moved into its current building on Roachton Road in the fall of 2001.
The school's athletic teams are known as the Yellow Jackets with school colors of black and gold and the school competes as a member of the Northern Lakes League.