The Perry County Courthouse is located at Main and Pine Streets in the commercial heart of Perryville, Arkansas, the seat of Perry County. It is a two-story brick building, with a hip roof. It is very simply styled, with rectangular two-over-two windows set in unadorned openings (some in pairs). Its main entrance is deeply recessed in an opening framed by pilasters and an entablatured, with multi-light sidelight windows to either side of the door. The courthouse was built in 1888, and was the county's third. It has been enlarged by single-story wings to either side.
The building was listed on the National Register of Historic Places in 1976.