Pepsin A (, pepsin, lactated pepsin, pepsin fortior, fundus-pepsin, elixir lactate of pepsin, P I, lactated pepsin elixir, P II, pepsin R, pepsin D) is an enzyme. This enzyme catalyses the following chemical reaction
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe<sup>1</sup>-Val, Gln<sup>4</sup>-His, Glu<sup>13</sup>-Ala, Ala<sup>14</sup>-Leu, Leu<sup>15</sup>-Tyr, Tyr<sup>16</sup>-Leu, Gly<sup>23</sup>-Phe, Phe<sup>24</sup>-Phe and Phe<sup>25</sup>-Tyr bonds in the B chain of insulin
The enzyme is a predominant endopeptidase in the gastric juice of vertebrates.
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