Penrose is a small town in the Southern Highlands of New South Wales, Australia, in Wingecarribee Shire. It has a station on the Main Southern railway line served by NSW TrainLink's Southern Highlands Line.
According to the , Penrose had a population of 247. At the 2021 census, there were 263 people recorded.
Penrose also has a small general store, a cafe, rural fire brigade, a primary school and a timber mill.