Penrod and Sam is a 1923 American silent comedy drama film directed by William Beaudine and starring Ben Alexander, Joe Butterworth, and Buddy Messinger. Wendy L. Marshall stated that "Beaudine had the Midas touch when it came to directing children" in films like this and Boy of Mine. In 1931, Beaudine directed a sound adaptation of the novel.
Prints of Penrod and Sam are in the collections of the Library of Congress and EYE Film Institute Netherlands.