Penile () is a historic community located in Jefferson County, Kentucky, United States. Formerly an unincorporated community, it was designated a neighborhood of Louisville, Kentucky, when the city of Louisville merged with Jefferson County in 2003.
The most prominent sights in Penile are a cemetery and Penile Baptist Church.
The origin of the neighborhood's name is believed to be attributed to the biblical place name of Penuel, (also spelled; Pneil, Pnuel; Hebrew: PÃÂnà «Ã¾ÃÂl) in the biblical books of and .