Pedesina is a comune (municipality) in the Province of Sondrio in the Italian region Lombardy, located about northeast of Milan and about southwest of Sondrio. As of 31 December 2008, it had a population of 33, and an area of . Pedesina borders the following municipalities: Bema, Gerola Alta, Premana, Rasura, Rogolo. It is one of the least populated municipalities in Italy, along with Morterone.