Paraguay competed at the 2011 Pan American Games in Guadalajara, Mexico from October 14 to 30, 2011. Gerardo Paniagua was the Chef de mission. Ben Hockin, a swimmer who won multiple medals at the 2010 South American Games, was selected to carry the flag during the opening ceremonies. Paraguay's delegation consisted of 28 athletes competing in 10 sports.
Paraguay qualified five athletes (four female and one male).
Paraguay qualified one female athlete in artistic roller skating.
Paraguay qualified two athletes in the rowing competition (one male and one female).
Paraguay qualified two shooters.
Paraguay qualified three athletes in the squash competition.
Paraguay qualified six swimmers (five male and one female).
Paraguay qualified one male athlete in table tennis.
Paraguay received one wild card in taekwondo.
Paraguay qualified five tennis players (three male and two female).
Paraguay received one wild card in the women's event.