Panther Branch is a long 2nd order tributary to Hyco Creek in Caswell County, North Carolina.
Panther Branch rises in Morgans Pond about 1 mile north of Prospect Hill, North Carolina, and then flows northerly to join Hyco Creek about 1.5 miles west-southwest of Frogsboro.
Panther Branch drains of area, receives about 46.5 in/year of precipitation, has a topographic wetness index of 376.53, and is about 45% forested.