Palazzuolo sul Senio (formerly Palazzolo di Romagna; Romagnolo: Palazol) is a comune (municipality) in the Metropolitan City of Florence in the Italian region Tuscany, located about northeast of Florence.
Palazzuolo sul Senio borders the following municipalities: Borgo San Lorenzo, Brisighella, Casola Valsenio, Castel del Rio, Firenzuola, Marradi.
Since 2018, it has been designated as one of I Borghi più belli d'Italia ("The most beautiful villages of Italy").