The Pain Killer Tour was the third headlining tour by American country music band Little Big Town. The tour was in support of their sixth studio album Painkiller (2014), and began on November 8, 2014, in Youngstown, Ohio. It concluded on November 21, 2015, in Spokane, Washington. Little Big Town consists of Karen Fairchild, Jimi Westbrook, Kimberly Schalpman and Philip Sweet.
Little Big Town first announced the tour in August 2014. Band member Karen Fairchild says, "We are so excited to share Pain Killer and get on the road for this tour", "Kimberly, Phillip, Jimi and I are thrilled to have such amazing openers in Brett and Brothers...we're big fans." The second leg was announced on December 15, 2015. The second leg of the tour was announced in December 2014. In May 2015, dates for the fall 2015 leg were announced.