Padgett's Creek Baptist Church is a historic Southern Baptist church located at 843 Old Buncombe Rd, Union, South Carolina near Cross Keys, Union County, South Carolina. It was built between 1844 and 1848, and is a plain, rectangular two-story meeting house building over slightly raised brick supports. The front has a portico added in 1958. There is also a one-story rear addition.
It was added to the National Register of Historic Places in 1971.