PORCN (porcupine homolog â Drosophila) is a human gene. The protein is homologous to other membrane-bound O-acyltransferases.
The protein encoded by this gene is an endoplasmic reticulum transmembrane protein involved in processing of wingless proteins such as WNT7A. It performs O-Palmitoleoylation of these proteins.
Mutations in this gene are associated with focal dermal hypoplasia.
Mutations in PORCN are associated to Goltz-Gorlin syndrome.
IWP (1-4)
RXC004