Plexin-B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.
Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins. Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.
PLXNB1 has been shown to interact with ARHGEF12, Rnd1 and ARHGEF11.